Anatomic pathology – Città della Salute e della Scienza university hospital
Scientific area: Oncology
SSD: MED/08 – Pathology
PI/Coordinator: Prof. Paola Cassoni
- Prof. Paola Cassoni, Group leader
- Prof. Isabella Castellano, Associate professor
- Dr. Luca Bertero, Associate professor
- Dr. Cristina Botta, Research technician
- Dr. Alessia Andrea Ricci: PhD student
- Dr. Luca Mangherini: PhD student
- Istituto di Anatomia Patologica
- Via Santena 7 - 10126 Torino – Italy
- Phone: 011/6334272 Fax: 011/6635267
- Email: paola.cassoni@unito.it
- Colorectal carcinoma: evaluation of innovative prognostic/predictive markers focusing on early invasive tumors (pT1); diagnostic improvement within colorectal screening programs.
- Breast and gynecological tumors: assessment of novel prognostic and predictive markers, molecular characterization of breast carcinoma and of neoplasms of female genital tract focusing on the role of steroid hormones receptors, Ki67 and tumor microenvironment.
- Central nervous system tumors (CNS): evaluation of innovative diagnostic tools; assessment and validation of histopathological and molecular prognostic markers in primary and secondary CNS neoplasms; characterization of the role of tumor microenvironment in tumor development and progression.
- Melanocytic neoplasms: prognostic factors and molecular profiling of melanocytic tumors focusing on metastatic melanoma.
- Digital/computational pathology: use of artificial intelligence-based tools for diagnostic workflow optimization and training/continuing medical education in Anatomic Pathology.
- Borella F, Cosma S, Ferraioli D, Ray-Coquard I, Chopin N, Meeus P, Cockenpot V, Valabrega G, Scotto G, Turinetto M, Biglia N, Fuso L, Mariani L, Franchi D, Urbinati AMV, Pino I, Bertschy G, Preti M, Benedetto C, Castellano I, Cassoni P, Bertero L. Clinical and Histopathologic Predictors Signaling Recurrence of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Multicenter Retrospective Cohort Study of Tertiary Centers. Ann Surg Oncol. 2022 Dec;29(13):8302-8314. doi: 10.1245/s10434-022-12353-y.
- Bertero L, Righi L, Collemi G, Koelsche C, Hou Y, Stichel D, Schrimpf D, Flucke U, Petersen I, Vokuhl C, Fröhling S, Bironzo P, Scagliotti GV, Cassoni P, Papotti M, von Deimling A. DNA methylation profiling discriminates between malignant pleural mesothelioma and neoplastic or reactive histological mimics. J Mol Diagn. 2021 Apr 19:S1525-1578(21)00090-8. doi: 10.1016/j.jmoldx.2021.04.002.
- Hou Y, Pinheiro J, Sahm F, Reuss DE, Schrimpf D, Stichel D, Casalini B, Koelsche C, Sievers P, Wefers AK, Reinhardt A, Ebrahimi A, Francisco F, Pusch S, Paulus W, Prinz M, Hartmann C, Plate K, Reifenberger G, Schüller U, Scheie D, de Stricker K, Hench J, Pollo B, Brandner S, Unterberg A, Meier J, Pfister S, Jones D, Korshunov A, Wick W, Capper D, Blümcke I, von Deimling A, Bertero L. Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA. Acta Neuropathol. 2019 May;137(5):837-846. doi: 10.1007/s00401-019-01969-2.
- Metovic J, Borella F, D'Alonzo M, Biglia N, Mangherini L, Tampieri C, Bertero L, Cassoni P, Castellano I. FOXA1 in Breast Cancer: A Luminal Marker with Promising Prognostic and Predictive Impact. Cancers (Basel). 2022 Sep 27;14(19):4699
- Metovic J, Bragoni A, Osella-Abate S, Borella F, Benedetto C, Gualano MR, Olivero E, Scaioli G, Siliquini R, Ferrando PM, Bertero L, Sapino A, Cassoni P, Castellano I. Clinical Relevance of Tubular Breast Carcinoma: Large Retrospective Study and Meta-Analysis. Front Oncol. 2021 Apr 29;11:653388.
- Rangel N, Rondon-Lagos M, Annaratone L, Aristizábal-Pachon AF, Cassoni P, Sapino A, Castellano I. AR/ER Ratio Correlates with Expression of Proliferation Markers and with Distinct Subset of Breast Tumors. Cells. 2020 Apr 24;9(4):1064.
- 2023 – 2026: ERA-NET TRANSCAN 3 Joint Transnational Call for Proposals 2021 (JTC 2021) “Next generation cancer immunotherapy: Targeting the tumour microenvironment” – Project: RISEBrain – Reverting immune suppression to elicit brain metastasis control – Role: Partner Unit – Coordinating units: CNIO – Centro Nacional de Investigaciones Oncológicas, Madrid, Spain and Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.
- 2021 – Today: Uterine smooth muscle cell neoplasms: analysis of novel prognostic markers and therapeutic targets – Funding: Cassa di Risparmio di Torino and Rete Oncologica del Piemonte e Valle d’Aosta
- 2019 – 2022: EU Horizon 2020 Call: H2020-ICT-2018-2 Topic: ICT-11-2018-2019 – Project: DeepHealth: Deep-Learning and HPC to Boost Biomedical Applications for Health – Role: Partner unit – Coordinating unit: everis Spain SLU. Website: Deep Health – Deep-Learning and HPC to Boost Biomedical Applications for Health (deephealth-project.eu)