Department of Medical Sciences

• Prof. Antonio D’Avolio, Head fo the team, PI, Associate Professor
• Dr.ssa Jessica Cusato, Associate Professor
• Dr. Mauro Sciandra, research tecnician
• Dr.  Amedeo De Nicolò, RTD B
• Dr.ssa Elisa Delia De Vivo
• Dr.ssa Alessandra Manca
• Dr. Jacopo Mula, research grant
• Dr.ssa Alice Palermiti, PhD
• Dr.ssa Miriam Antonucci, Biomedical laboratory technician (ASL)
• Dr.ssa Sara Soloperto, Fellow
• Dr.ssa Martina Billi, Fellow
• Dr. Domenico Maiese, Fellow (ASL)
• Dr.ssa Giorgia Menegatti, Fellow

• Padiglione Q, “Amedeo di Savoia” Hospital, C.so Svizzera 164, 10149 Torino (Italy)
• Tel. Seg. +39.011.4393979
• Tel. Lab. +39.011.4393867
• Fax: +39.011.4393882/3882
• e-mail: info@tdm-torino.org

• Prof. Antonio D’Avolio
• Prof.ssa Jessica Cusato
• Dr. Amedeo De Nicolò
• Prof. Antonio D’Avolio

The research and clinical activity of the group directed by Prof. D'Avolio (Associate Professor of Pharmacology) at the University of Turin and at the Amedeo di Savoia Hospital of the ASL City of Turin), as head of the "Laboratory of Pharmacology Clinical and Pharmacogenetics" (Laboratory certified for Phase I AIFA, UNI EN ISO 9001 and 13485 for CE-IVD), has been held since 2006 on the following topics: clinical pharmacology; study of pharmacogenetics; the management and personalization of therapy in patients;

• clinical pharmacology of anti-infectives, cancer drugs (including tyrosine kinase inhibitors, mitotane, etc.), antihypertensive drugs, iron chelators, monoclonal antibodies, anti SARS-CoV-2 drugs and therapies, etc.;
• management of therapy personalization in patients; intracellular and tissue pharmacokinetic evaluation of anti-infectious and non-infectious drugs, including through the use of clinically applied pharmacogenetics in patients receiving chemotherapy (as part of clinical routine and clinical trials).
• Routine diagnostic analysis for clinical biological samples arriving at the laboratory for "therapeutic drug monitoring" (drug quantification) and pharmacogenetic testing (evaluation of single nucleotide polymorphisms).

List of publications of the last 3 years

1. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Antonio D’Avolio, Valeria Avataneo, Alessandra Manca, Jessica Cusato, Amedeo De Nicolò, Renzo Lucchini, Franco Keller and Marco Cantù; Nutrients 2020, 12(5), 1359; https://doi.org/10.3390/nu12051359

1. An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new nonnucleoside reverse transcriptase inhibitor etravirine, and 11 other antiretroviral agents in the plasma of HIV-infected patients; Antonio D'Avolio 1, Lorena Baietto, Marco Siccardi, Mauro Sciandra, Marco Simiele, Valentina Oddone, Stefano Bonora, Giovanni Di Perri; Ther Drug Monit. 2008 Dec;30(6):662-9. doi: 10.1097/FTD.0b013e318189596d.

1. Intracellular accumulation of atazanavir/ritonavir according to plasma concentrations and OATP1B1, ABCB1 and PXR genetic polymorphisms; Antonio D'Avolio, Chiara Carcieri, Jessica Cusato, Marco Simiele, Andrea Calcagno, Sarah Allegra, Mauro Sciandra, Laura Trentini, Giovanni Di Perri, Stefano Bonora. J Antimicrob Chemother, . 2014 Nov;69(11):3061-6. doi: 10.1093/jac/dku234.

1. Cannabinoids concentration variability in cannabis olive oil galenic preparations. Chiara Carcieri, Cristina Tomasello, Marco Simiele, Amedeo De Nicolò, Valeria Avataneo, Luca Canzoneri, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio. J Pharm Pharmacol. . 2018 Jan;70(1):143-149. doi: 10.1111/jphp.12845

1. Association of ITPA polymorphisms rs6051702/rs1127354 instead of rs7270101/rs1127354 as predictor of ribavirin-associated anemia in chronic hepatitis C treated patients. Antonio D'Avolio, Amedeo De Nicolò, Jessica Cusato, Alessia Ciancio, Lucio Boglione, Silvia Strona, Giuseppe Cariti, Giulia Troshina, Gian Paolo Caviglia, Antonina Smedile, Mario Rizzetto, Giovanni Di Perri. Antiviral Res. . 2013 Oct;100(1):114-9. doi: 10.1016/j.antiviral.2013.07.021.

• Eccellenza
• DERIVE - Virtual consortium (interantional project; network EDCTP2)
• RemTLaR-CAPACT 2 (interantional project; network EDCTP2)
• RIBET (national research project, with competitive call)
•  MARISA (PRIN 2020)
• MONET (national research project, with competitive call)
• SILK (POR PIEMONTE FESR 2014/2020 - INFRA-P 2 Line B)
• FAST-COV (FISR 2020 Covid)
• PRIN 2017

Constitution of the spin-off and innovative start-up CoQua Lab (www.coqualab.it)