• Prof. Giuseppe Montrucchio (Full Professor; Head of Group)
• Prof. Enrico Lupia (Associate Professor; RADRL)
• Dott. Fulvio Morello (Associate Professor)
• Dr. Ornella Bosco (Research Technician)
• Dr. Barbara Vizio (Research Technician)
• Dr. Emanuele Pivetta (RTDB)
• Dr. Martina Schiavello (PhD student)
• Dr. Adriana Prati (Research Technician)
• Dr. Elisabetta Greco (MD)
• Dr. Eleonora Lumia (Student, Master's Degree in Medical Biotechnology)
• Dr. Emanuele Pivetta (MD)
• Dr. Chiara Dini (Student, Master's Degree in Medical Biotechnology)
• Dr. Loris Delmastro (MD, School of Specialization in Emergency Medicine)
• Dr. Giordano Bianchi (MD)

• Prof. Giuseppe Montrucchio
• Fisiopatologia degli stati critici
• Laboratorio di “Biologia Cellulare e Molecolare applicata agli stati critici della Medicina Interna”
• Dipartimento di Scienze mediche - Università di Torino
• Via Genova 3 - 10126 Torino
• giuseppe.montrucchio@unito.it
• tel: +390116705390
• fax: +390116705363

• Prof. Giuseppe Montrucchio 
• Prof. Enrico Lupia 
• Prof. Fulvio Morello
• Dott. Emanuele Pivetta
• Dott.ssa Ornella Bosco 
• Dott.ssa Barbara Vizio

• study of platelet function, leukocyte-platelet interaction and humoral mediators involved in critical diseases such as acute coronary syndrome, acute renal failure, sepsis / septic shock, acute aortic syndrome, cardiovascular complications of diabetic disease and acute respiratory disease from SARS- CoV-2 (COVID-19);
• biomolecular study of the immunopathological mechanisms that control the growth process of gastrointestinal and hepatic tumors;
• study on the diagnostic and prognostic ability of circulating biomarkers (proteins and miRNA) in patients with critical pathology such as acute heart failure, septic shock, acute aortic syndrome and COVID-19;
• study of the role of extracellular vesicles in cardiovascular alteration during sepsis;
• evaluation of the 1st level clinical ultrasound role in the diagnosis and prognostic stratification of acute diseases (acute heart failure, syncope, respiratory failure, COVID-19)
• study of platelet function, leukocyte-platelet interaction and humoral mediators involved in
  critical diseases such as acute coronary syndrome, acute renal failure, sepsis / septic shock,
  acute aortic syndrome, and SARS- CoV-2 infection;
• biomolecular study of the immunopathological mechanisms that control the growth process
  of gastrointestinal and hepatic tumors;
• study on the diagnostic and prognostic ability of circulating biomarkers (proteins and
  miRNA) in patients with critical pathology such as acute heart failure, septic shock, acute
  aortic syndrome and SARS- CoV-2 infection;
• characterization of the extracellular vesicles in the critically ill patient and evaluation of
  their role in the development of organ damage in the burn patient and/or with sepsis/septic
  shock;
• evaluation of the 1st level clinical ultrasound role in the diagnosis and prognostic
• stratification of acute diseases (acute heart failure, syncope, respiratory failure, SARS- CoV-
  2 infection)

List of publications of the last 3 years

1. Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation.
   Schiavello M, Vizio B, Bosco O, Pivetta E, Mariano F, Montrucchio G, Lupia E. Int J Mol Sci. 2023 Jan 18;24(3):1920. doi: 10.3390/ijms24031920. PMID: 36768242 Review
2. Thrombopoietin participates in platelet activation in COVID-19 patients.Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G. EBioMedicine. 2022 Nov;85:104305. doi: 10.1016/j.ebiom.2022.104305. Epub 2022 Oct
   13. PMID: 36242922
3. Cooperative Role of Thrombopoietin and Vascular Endothelial Growth Factor-A in the Progression of Liver Cirrhosis to Hepatocellular Carcinoma. Vizio B, Bosco O, David E, Caviglia GP, Abate ML, Schiavello M, Pucci A, Smedile A, Paraluppi G, Romagnoli R, Lupia E, Bellone G, Montrucchio G. Int J Mol Sci. 2021 Feb 12;22(4):1818. doi: 10.3390/ijms22041818. PMID: 33673041
4. Lung Ultrasonography for the Diagnosis of SARS-CoV-2 Pneumonia in the Emergency Department.Pivetta E, Goffi A, Tizzani M, Locatelli SM, Porrino G, Losano I, Leone D, Calzolari G,
   Vesan M, Steri F, Ardito A, Capuano M, Gelardi M, Silvestri G, Dutto S, Avolio M, Cavallo R, Bartalucci A, Paglieri C, Morello F, Richiardi L, Maule MM, Lupia E; Molinette
   MedUrg Group on Lung Ultrasound. Ann Emerg Med. 2021 Apr;77(4):385-394. doi: 10.1016/j.annemergmed.2020.10.008. Epub 2020 Oct 13. PMID: 33461884
5. Development and Validation of a Simplified Probability Assessment Score Integrated With Age-Adjusted d-Dimer for Diagnosis of Acute Aortic Syndromes. Morello F, Bima P, Pivetta E, Santoro M, Catini E, Casanova B, Leidel BA, de Matos Soeiro A, Nestelberger T, Mueller C, Grifoni S, Lupia E, Nazerian P. J Am Heart Assoc. 2021 Feb 2;10(3):e018425. doi: 10.1161/JAHA.120.018425. Epub 2021 Jan 21. PMID: 33474974

Ricerca Locale ex-60% (2022) - PIVE_RILO_22_01  

∙ Evaluation of extracellular vesicles as biomarker in COVID19 patients 

Bando GRANT for INTERNATIONALIZATION: LUCEAT - PIVE_GFI_22_01_F  ∙ Lung Ultrasound and Chest radiography Evaluation Among Trainees. 

Ricerca locale ex-60% (2021) - VIZB_RILO_21_01  

∙ Plasma microRNA expression revealing potential biomarkers in COVID19 patients. 

Ricerca Locale ex 60% (2021) - MORF_RILO_21_02  

∙ PRospective Evaluation of the European Society of Cardiology 0/1halgorithm`s Safety and  Efficacy for Triage of Patients with Suspected Myocardial Infarction (PRESC1SE-MI trial). 

Ricerca locale ex-60% (2020) - MONG_RILO_20_01 

∙ Evaluation of extracellular vesicles as biomarker in sepsis and septic shock. 

Ricerca locale ex-60% (2020) - LUPE_RILO_20_01 

∙ Analysis of platelet mitochondrial dysfunction during sepsis. 

Ricerca Locale ex-60% (2020) - MORF_RILO_20_03 

∙ Development and validation of a new simplified risk score and diagnostic rule for acute  aortic syndromes: analyses on multiple cohorts and new multicenter multinational  prospective study in the Emergency Department.