• Prof.ssa Silvia Deaglio(Coordinator)
• Prof.ssa Tiziana Vaisitti (Coordinator)
• Dott. Francesca Arruga  (Post-doc)
• Dott.ssa Fascì Amelia (Fellow)
• Dott. Andrea Iannello (Post-doc)
• Dott.ssa Adriana Saba (Post-doc)
• Dott. Vincenzo Gianluca Messana  (PhD Student)
• Dott. Lorenzo Brandimarte   (PhD Student)
• Dott. Benjamin Baffour Gyaou (PhD Student)
• Dott.ssa Giulia Omezzolli (PhD Student)
• Dott.ssa Monica Sorbini (PhD Student)
• Dott. Francesco Edoardo Vallone (Studente PhD)
• Dott. Nahal Nabelsi (Studente PhD)
• Dott. Micillo Matilde (PhD Student)
• Dott.ssa Martina Migliorero (PhD Student)

Silvia Deaglio

• Molecular Biotechnology Center MBC, Via Nizza 52, 10126 Torino.
• Email: silvia.deaglio@unito.it;
• Phone: +39 (011) 6709535

Tiziana Vaisitti

• Molecular Biotechnology Center MBC, Via Nizza 52, 10126 Torino.
• Email: tiziana.vaisitti@unito.it;
• Phone: +39 (011) 6709535

• Prof.ssa Silvia Deaglio
• Prof.ssa Tiziana Vaisitti

1. Characterization of micro-environmental factors and genetic and molecular mechanisms that regulate tumor-host interactions in B lymphoproliferative syndromes. Attention is focused on nucleotides metabolizing enzymes express on the cell surface or in the cytoplasm 
2. Characterization of the cross-talk between oncogenic signals and intra-cellular metabolism.
3. Characterization of the genetic, epigenetic and metabolic profile of Richter syndrome and set up of in vitro and in vivo model to design novel therapeutic approaches. 
4. Identification of novel recurrently mutated genes in B lymphoproliferative syndromes and analysis of their biological role by genome editing exploiting the  CRISPR/Cas9 technique.
5. Functional validation of genetic variants causative of monogenic diseases leading to organ failure.

• Prof.ssa Silvia Deaglio
• Prof.ssa Tiziana Vaisitti

1. Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.  Arruga F, Bracciamà V, Vitale N, Vaisitti T, Gizzi K, Yeomans A, Coscia M, D'Arena G, Gaidano G, Allan JN, Furman RR, Packham G, Forconi F, Deaglio S. Leukemia. 2020 Feb;34(2):462-477. doi: 10.1038/s41375-019-0571-0. Epub 2019 Aug 29. PMID: 31467429
2. Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia. Arruga F, Serra S, Vitale N, Guerra G, Papait A, Baffour Gyau B, Tito F, Efremov D, Vaisitti T, Deaglio S. Haematologica. 2021 May 1;106(5):1343-1353. doi: 10.3324/haematol.2019.242016. PMID: 32299906 
3. Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma.  Audrito V, Managò A, La Vecchia S, Zamporlini F, Vitale N, Baroni G, Cignetto S, Serra S, Bologna C, Stingi A, Arruga F, Vaisitti T, Massi D, Mandalà M, Raffaelli N, Deaglio S. J Natl Cancer Inst. 2018 Mar 1;110(3). doi: 10.1093/jnci/djx198. PMID: 29309612
4. Synergistic efficacy of dual PI3K-d/g inhibitor Duvelisib with Bcl2 inhibitor Venetoclax in Richter's Syndrome PDX models. Iannello A, Vitale N, Coma S, Arruga F, Chadburn A, Di Napoli A, Laudanna C, Allan J, Furman RR, Pachter JA, Deaglio S, Vaisitti T. Blood. 2021 Mar 30:blood.2020010187. doi: 10.1182/blood.2020010187. Online ahead of print. PMID: 33786583
5. ROR1 targeting with the antibody drug-conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. Vaisitti T, Arruga F, Vitale N, Lee TT, Ko M, Chadburn A, Braggio E, Di Napoli A, Iannello A, Allan J, Miller LL, Lannutti BJ, Furman RR, Jessen K, Deaglio S. Blood. 2021 Jan 14:blood.2020008404. doi: 10.1182/blood.2020008404. Online ahead of print. PMID: 33512452

• European Union H2020 funds, Progetto INTEGRATA #813284 (PI: Silvia Deaglio)
• Italian Ministry of Education, University and Research, Progetto PRIN 2017 “Understanding and targeting the extracellular NADome in inflammation”
• Italian Ministry of Education, University and Research - Progetto strategico di Eccellenza Dipartimentale #D15D18000410001 (PI of one Research Unit: Silvia Deaglio)
• Italian Association for Cancer Research AIRC#23095 “A ménage a trois involving the B cell receptor, NOTCH1 and NAMPT: Therapeutic implications for CLL and RS patients” (PI: Silvia Deaglio)
• Italian Ministry of Health, Young Investigator Grant #GR-2016-02364298; 2018-2021 “Highlighting the tumorigenic role of long non coding RNA in patients with Anaplastic Large cell Lymphoma” (OPI of one research Unit: Tiziana Vaisitti)
• Italian Association for Cancer Research AIRC#23107 “Probing Richter’s syndrome by multiple “omics” approaches to find its Achille’s heel” (PI: Tiziana Vaisitti)