• Maria Felice Brizzi - Coordinator, Associate Professor
• Stefania Bruno - Group leader, Associate Professor
• Dr.ssa Cristina Grange, Tecnico della Ricerca
• Dr. Alessandro Sarcinella, PhD student
• Dr. Gabriele Saccu, PhD student
• Dr.ssa Giulia Chiabotto, post-Doc
• Dr.ssa Elena Ceccotti, PhD student
• Dr.ssa Saveria Femminò, post-Doc

• Laboratory n. 7 (T151): Laboratory of Molecular Biology
• Laboratory n. 13 (T143): Laboratory for the functional study of tumoral extracellular vesicles
• Laboratory n. 14 (T148): Laboratory of proteomic of cardiovascular diseases
• Laboratory n. 9: Laboratory of translational research: isolation and functional of extracellular vesicles for tissue regeneration

Ospedale Molinette, piano terra, Corso Dogliotti 14, Torino

• mariafelice.brizzi@unito.it, 011/6336703
• stefania.bruno@unito.it, 011/6335539

• Prof.ssa Maria Felice Brizzi
• Dott. Stefania Bruno

1. Isolation and phenotypical, molecular and functional characterizathion of extracellular vesicles derived from different sources. 
2. Evaluation of pro-regenerative capacity of extra-cellular vesicles derived from human adult stem cells in different acute and chronic kidney diseases.
3. Study of the anti-fibrotic and anti-inflammatory activities of extra-cellular vesicles derived from human adult stem cells in different in vitro and in vivo models of hepatic fibrosis. 
4. Analyses of therapeutic targets in tumors of different origin. 
5. New therapeutic approaches using extra-cellular vesicles derived from serum of patients with vascular disease. 
6. Study of the mechanisms of tumor immunosuppression mediated by extra-cellular vesicles.

• Pubblicazioni - ultimi 3 anni

• Chiabotto G, Ceccotti E, Tapparo M, Camussi G, Bruno S. Human Liver Stem Cell-Derived Extracellular Vesicles Target Hepatic Stellate Cells and Attenuate Their Pro-fibrotic Phenotype. Front Cell Dev Biol. 2021, 9:777462. 
• Bruno S, Chiabotto G, Cedrino M, Ceccotti E, Pasquino C, De Rosa S, Grange C, Tritta S, Camussi G. Extracellular Vesicles Derived from Human Liver Stem Cells Attenuate Chronic Kidney Disease Development in an In Vivo Experimental Model of Renal Ischemia and Reperfusion Injury. Int J Mol Sci. 2022;23(3):1485. 
• Gibello L, D'Antico S, Salafia M, Senetta R, Pomatto MAC, Orlando G, Sarcinella A, Lopatina T, Quaglino P, Lorenzi M, Verzini F, Camussi G, Brizzi MF. First pilot case-control interventional study using autologous extracellular vesicles to treat chronic venous ulcers unresponsive to conventional treatments. Pharmacol Res. 2023 Mar 5;190:106718. doi: 10.1016/j.phrs.2023.106718.
• Koni M, Castellano I, Venturelli E, Sarcinella A, Lopatina T, Grange C, Cedrino M, Femminò S, Cossu-Rocca P, Orrù S, D'Ascenzo F, Cotellessa I, Tampieri C, Debernardi C, Cugliari G, Matullo G, Camussi G, De Miglio MR, Brizzi MF. Interleukin-3-Receptor-α in Triple-Negative Breast Cancer (TNBC): An Additional Novel Biomarker of TNBC Aggressiveness and a Therapeutic Target. Cancers (Basel). 2022 Aug 13;14(16):3918. doi: 10.3390/cancers14163918.
• Lopatina T, Koni M, Grange C, Cedrino M, Femminò S, Lombardo G, Favaro E, Brizzi MF. IL-3 signalling in the tumour microenvironment shapes the immune response via tumour endothelial cell-derived extracellular vesicles. Pharmacol Res. 2022 May;179:106206. doi: 10.1016/j.phrs.2022.106206.

• PNRR: Drugs based on RNA technology. SPOKE: Cellular-derived vesicles as delivery system for RNA-based drugs.

• US11464799B2 (MF Brizzi, G. Camussi, A Ranghino). COMPOSITION OF EXTRACELLULAR VEPNRR: Drugs based on RNA technology. SPOKE: Cellular-derived vesicles as delivery system for RNA-based drugs.SICLES (EVS) AND MEDICAL USES THEREOF(Publication Date: 2022-10-11)

• US11110130B2 (MF Brizzi, G. Camussi). PHARMACEUTICAL CARRIERS CONTAINING MIRNAS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES CAUSED BY HYPERGLYCEMIA (Publication Date: 2021-09-07)

• EA037967B1 (G. Camussi MF Brizzi). PHARMACEUTICAL CARRIERS CONTAINING MIRNAS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES CAUSED BY HYPERGLYCEMIA (Publication Date: 2021-06-16)

• EP3010529B1 (MF Brizzi, E. Ghigo). USE OF UNACYLATED GHRELIN, FRAGMENTS AND ANALOGS THEREOF AS ANTIOXIDANT (Publication Date: 2020-05-06)

• EP3452100B1 (MF Brizzi, G. Camussi). PHARMACEUTICAL CARRIERS CONTAINING MIRNAS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES CAUSED BY HYPERGLYCEMIA (Publication Date: 2020-12-16)

• US10716813B2 (MF Brizzi, G. Camussi). PHARMACEUTICAL CARRIERS CONTAINING MIRNAS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES CAUSED BY HYPERGLYCEMIA Publication Date: 2020-07-21

• CA2723270C (G. Muccioli, E. Ghigo, MF Brizzi) UNACYLATED GHRELIN AND ANALOGS AS THERAPEUTIC AGENTS FOR VASCULAR REMODELING IN DIABETIC PATIENTS AND TREATMENT OF CARDIOVASCULAR DISEASE (Publication Date: 2018-03-13)

• AU2009256558B2 (E. Ghigo, G. Muccioli, MF Brizzi). UNACYLATED GHRELIN AND ANALOGS AS THERAPEUTIC AGENTS FOR VASCULAR REMODELING IN DIABETIC PATIENTS AND TREATMENT OF CARDIOVASCULAR DISEASE (Publication Date: 2014-03-06)

• EP2310041B1 (MF Brizzi, G. Muccioli, E. Ghigo). UNACYLATED GHRELIN AND ANALOGS AS THERAPEUTIC AGENTS FOR VASCULAR REMODELING IN DIABETIC PATIENTS AND TREATMENT OF CARDIOVASCULAR DISEASE  (Publication date 2013-02-13)

• DK3452100T3 (G. Camussi, MF Brizzi). FARMACEUTISKE BÆRERE INDEHOLDENDE miRNAer TIL ANVENDELSE I BEHANDLINGEN AF FIBROTISKE SYGDOMME FORÅRSAGET AF HYPERGLYKÆMIA (Publication Date: 2021-03-08)

• ES2861650T3. PORTADORES FARMACÉUTICOS QUE CONTIENEN MIARN PARA SU USO EN EL TRATAMIENTO DE ENFERMEDADES FIBRÓTICAS PROVOCADAS POR HIPERGLUCEMIA (Publication Date: 2021-10-06)

• International patent: Bruno Stefania, Herrera Maria B)etariz, Fonsato Valentina, Camussi Giovanni, Tetta Ciro. (2011). “Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease”. WO2011107437 (A1)

• International patent: Camussi Giovanni, Bruno Stefania, Bussolati Benedetta (2011). “Isolated multipotent mesenchymal stem cells from human adult glomeruli (HGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney”. US2011256111 (A1), EP2186883 (A1)

• interviews with secondary school students for the project “STEM women”