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Genetics and molecular biology of arterial hypertension

 

SSD: MED09 –Internal Medicine
PI/Coordinator: Prof. Paolo Mulatero

Prof. Paolo Mulatero, Full Professor of Internal Medicine – University of Torino

  • Azienda Città della Salute e della Scienza di Torino, Sede Molinette
  • Division of Internal Medicine 4 and Hypertension Unit
  • Via Genova 3, 10126 Torino
  • paolo.mulatero@unito.it
  • Phone: +390116336997
  • Fax: +390116336931

  • Clinical studies on prevalence and subtype diagnosis of primary aldosteronism; role of adrenal vein sampling and hybrid steroids; development of clinical scores for diagnosis and management of primary aldosteronism
  • Histopathology and immunohistochemistry of aldosterone producing adenomas
  • Genetics of sporadic and familial primary aldosteronism and low renin hypertension; diagnosis of familial forms of arterial hypertension
  • Molecular mechanisms responsible for autonomous aldosterone production in sporadic and familial primary aldosteronism
  • Characterization of circulating extracellular vescicles in patients affected by primary aldosteronism and their role in cardio-vascular risk stratification
  • Characterization of urinary and circulating extracellular vesicles in patients undergoing dietary sodium modulation

  1. TSPAN12 (Tetraspanin 12) is a novel negative regulator of aldosterone production in adrenal physiology and aldosterone-producing adenomas. Gong S, Tetti M, Kemter E, Peitzsch M, Mulatero P, Bidlingmaier M, Eisenhofer G, Wolf E, Reincke M, Williams TA. Hypertension. 2023 Feb;80(2):440-450
  2. Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature. Burrello J, Burrello A, Vacchi E, Bianco G, Caporali E, Amongero M, Airale L, Bolis S, Vassalli G, Cereda CW, Mulatero P, Bussolati B, Camici GG, Melli G, Monticone S, Barile L. Transl Res. 2022 Jun;244:114-125
  3. Characterization of circulating extracellular vesicle surface antigens in patients with primary aldosteronism. Burrello JTetti M, Forestiero V, Biemmi V, Bolis S, Pomatto MAC, Amongero M, Di Silvestre D, Mauri P, Vassalli G, Camussi G, Williams TA, Mulatero P, Barile L, Monticone S. Hypertension. 2021 Sep;78(3):726-737. 
  4. Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis. Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P. Lancet Diabetes Endocrinol. 2018 Jan;6(1):41-50.
  5. Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice. Monticone SBurrello J, Tizzani D, Bertello C, Viola A, Buffolo F, Gabetti L, Mengozzi G, Williams TA, Rabbia F, Veglio F, Mulatero P. J Am Coll Cardiol. 2017 Apr 11;69(14):1811-1820.

  • HORIZON-HLTH-2022-TOOL-11-01. Project title: Improving treatment efficacy in hypertension by biomarker-guided personalised decision support. Acronym: HT-ADVANCE. Role: collaborator. Paolo Mulatero e Silvia Monticone local PI.
  • 2022-2024 Swiss Heart Foundation. Research Grant 2022 application (FF22064) Project title: EV Surface Markers in Acute Cerebrovascular Syndromes. ElViS –ACS study. Role: collaborator (Jacopo Burrello)
  • 2022-2024 PNRR. Gene therapy and therapy based on RNA technology. Project title: Cellular-derived vesicles as delivery system for RNA-based drugs. Role: collaborator (Jacopo Burrello)
  • 2021-2022 Michael J. Fox Foundation for Parkinson’s Research. Fall 2020 RFA: Parkinson's Pathway Biomarkers. MJFF Grant ID: MJFF-000965. Project title: Multiplexed immune-phenotyping of plasma-derived extracellular vesicles as biomarker for early Parkinson’s disease. Role: collaborator (Jacopo Burrello)
  • H2020-PHC-2014 progetto ENSAT-HT 633983. Project title: Application of omics-based strategies for improved diagnosis and treatment of endocrine hypertension (local PI: Paolo Mulatero; Tracy A Williams; Silvia Monticone, participant)
  • Ricerca Locale 2021 "Effect of dietary sodium modulation on circulating extracellular vesicles" Role: PI Silvia Monticone
  • Ricerca Locale 2022 - Characterization of circulating extracellular vesicles as non-invasive biomarkers of rejection in heart transplant recipients. Role: PI Jacopo Burrello
Last update: 15/05/2023 09:15
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