The role of chronic infections such as HIV, HCV, toxoplasmosis, and herpetic infections, in neurodegeneration and accentuated/accelerate brain aging, inflammation of the central nervous system, blood-brain barrier impairment, and neuronal and glial toxicity.
The role of chronic infections in neurocognitive disorders, dementias, and mood disorders (e.g., depression).
In collaboration with the Pharmacology and Pharmacogenetics Laboratory of the University
of Turin (Prof. Antonio D’Avolio, Prof. Jessica Cusato) study of cerebrospinal fluid and intracellular concentrations of antivirals and antibiotics.
The study of clinical and cognitive phenotypes and the implementation of tailored management of HIV-associated neurocognitive disorders.
Serum and cerebrospinal fluid biomarkers, imaging and alternative diagnostics (EEG, nasal brushing) for the diagnosis of central nervous system infections and for the follow up of individuals with long-term complications associated with infections of the central nervous system.
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PMID: 36352195. Trunfio M, Di Girolamo L, Ponzetta L, Russo M, Burdino E, Imperiale D, Atzori C, Di Perri G, Calcagno A. Seropositivity and reactivations of HSV-1, but not of HSV-2 nor VZV, associate with altered blood-brain barrier, beta amyloid, and tau proteins in people living with HIV. J Neurovirol. 2022 Nov 9. doi: 10.1007/s13365-022-01105-z. Epub ahead of print.
PMID: 35458483. Trunfio M, Atzori C, Pasquero M, Di Stefano A, Vai D, Nigra M, Imperiale D, Bonora S, Di Perri G, Calcagno A. Patterns of Cerebrospinal Fluid Alzheimer's Dementia Biomarkers in People Living with HIV: Cross-Sectional Study on Associated Factors According to Viral Control, Neurological Confounders and Neurocognition. Viruses. 2022 Apr 4;14(4):753. doi: 10.3390/v14040753.
PMID: 34982319. Trunfio M, De Francesco D, Vai D, Medina C, Milesi M, Domini S, Alcantarini C, Imperiale D, Bonora S, Di Perri G, Calcagno A. Screening Accuracy of Mini Addenbrooke's Cognitive Examination Test for HIV-Associated Neurocognitive Disorders in People Ageing with HIV. AIDS Behav. 2022 Jul;26(7):2203-2211. doi: 10.1007/s10461-021-03563-8. Epub 2022 Jan 4.
PMID: 31130152. Di Stefano A, Alcantarini C, Atzori C, Lipani F, Imperiale D, Burdino E, Audagnotto S, Mighetto L, Milia MG, Di Perri G, Calcagno A.Cerebrospinal fluid biomarkers in patients with central nervous system infections: a retrospective study. CNS Spectr. 2020 Jun;25(3):402-408. doi: 10.1017/S1092852919000981.
PMID: 35044644. Barco A, Orlando S, Stroffolini G, Pirriatore V, Lazzaro A, Vai D, Guastamacchia G, Noce G, Atzori C, Trunfio M, Bonora S, Di Perri G, Calcagno A. Correlations between cerebrospinal fluid biomarkers, neurocognitive tests, and resting-state electroencephalography (rsEEG) in patients with HIV-associated neurocognitive disorders. J Neurovirol. 2022 Apr;28(2):226-235. doi: 10.1007/s13365-021-01047-y.
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“Clinical and virologic relevance and long-term impact of cerebrospinal fluid HIV viral escape”, RF-2019-12371089, funded by Ministry of Health, Italy; in collaboration with National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, and Infectious Diseases Unit, ASST Santi Paolo e Carlo, University of Milan.
“Cerebrospinal fluid virome and microbiome in people living with HIV”, Gliead Fellowship 2021, Gilead Science Italy; in collaboration with University of Milan, Department of Oncology and Hemato-Oncology (Milan, Italy), and Multimodal Research Area, Bambino Gesù Children Hospital IRCCS (Rome, Italy).
SOLFAMU prospective study “Study of nasal brushing collected OLFActory MUcosa samples in the diagnosis of human encephalopathies”, Clinical Trial number NCT02951559.
Collaboration with international centers of excellence in the field of our research, such as the HIV Neurobehavioral Research Center HNRC, University of California San Diego (San Diego, CA, USA), Department of Infectious Disease and HIV Medicine, Imperial College and Institute for Global Health, University College London (London, UK), Department of Infectious Diseases, University of Gothenburg (Gothenburg, Sweden), Department of Microbiology and Immunology, University of North Carolina at Chapel Hill (Chapel Hill, NC, USA), Orange Clinic, Royal Sussex County Hospital, University of Sussex (Brighton, UK), and Infectious Diseases Institute, Makerere University (Kampala, Uganda); latest publications in collaboration: PMID: 34127578; PMID: 34747481; PMID: 31790378; PMID: 30800328; PMID: 34982319.
