Epidemiology and biostatistics
SSD: MED/01
Head of the group: Prof. Lorenzo Richiardi
- Lorenzo Richiardi, PO, Responsabile del gruppo
- Milena Maule, PA
- Daniela Zugna, PA
- Costanza Pizzi, RTDB
- Maja Popovic, RTDA
- Giovenale Moirano, Specializzando
- Chiara Moccia, Dottoranda
- Antonio D’Errico, Dottorando
- Silvia Maritano, Dottoranda
- Nicolas Destefanis, Dottorando
- Juthathip Khongpetch, Dottoranda
- Elena Isaevska, Assegnista di ricerca
- Laura Davico, Tecnico della ricerca
- Emanuela Ciliberto, Tecnico della ricerca
- Hirad Akberi Afkhami, Specializzando
- Paolo Vasapolli, assegnista di ricerca
- Valentina Fiano, Tecnico della Ricerca
- Epidemiologia dei Tumori, Via Santena 7, Palazzina di Anatomia Patologica, piano rialzato
- mail: lorenzo.richiardi@unito.it, tel +39 011 633.4673, fax +39 011 633.4664
- Prof. Lorenzo Richiardi
- Prof. Milena Maule
- Prof. Daniela Zugna
- Dott. Costanza Pizzi
- Dott. Maja Popovic
- Etiological epidemiology: we investigate the causes of different types of cancer and some chronic diseases, including asthma, cardiovascular diseases, and diabetes, with a focus on the effects of lifestyle, environmental and occupational exposures, genetic variants, and gene-environment interaction.
- Life-course epidemiology: we have recruited and follow up over time population, occupational, and birth cohorts to study the effects of exposures acting in utero, in early life, and throughout the life course on child and adult health. In particular, we are responsible for the NINFEA Project and the Turin center of the Piccolipiù cohort.
- Clinical epidemiology: we conduct diagnostic, prognostic, translational and efficacy studies aimed at improving knowledge and treatment of various cancers and other chronic and infectious diseases.
- Molecular epidemiology: we conduct translational studies aimed at the potential improvement of clinical guidelines through bio-molecular analyses for the identification of diagnostic or prognostic markers of different types of cancer. Areas of interest include viral carcinogenesis and genetic and epigenetic alterations.
- Exposomics: we conduct studies aimed at examining the health effect of multiple environmental exposures (general external environment, specific external environment, molecular internal environment) to which people are exposed from conception onwards, thus using a systematic approach.
- Piedmont Cancer Registry, Piedmont Childhood Cancer Registry, and Piedmont Malignant Mesothelioma Registry: we contribute to the cancer registration activities of the SC Cancer Epidemiology, both methodologically and by nesting in the cancer registries analytical, etiologic, and quality-of-life studies of cancer patients.
- Epidemiological methods and biostatistics: our methodological research concerns the development and application of modern approaches for the analysis of population studies in the fields of causal inference, prediction models, longitudinal studies, analysis of "omics" data, and integration of causal inference and machine learning methods.
- Pubblicazioni - ultimi 3 anni
- Pubblicazioni Prof. L. Richiardi
- Zelic R, Fiano V, Zugna D, Grasso C, Delsedime L, Daniele L, Galliano D, Pettersson A, Gillio-Tos A, Merletti F, Richiardi L. Global Hypomethylation (LINE-1) and Gene-Specific Hypermethylation (GSTP1) on Initial Negative Prostate Biopsy as Markers of Prostate Cancer on a Rebiopsy. Clin Cancer Res. 2016 Feb 15;22(4):984-92. doi: 10.1158/1078-0432.CCR-15-0606
- Maritano S, Moirano G, Popovic M, D'Errico A, Rusconi F, Maule M, Richiardi L. Maternal pesticides exposure in pregnancy and the risk of wheezing in infancy: A prospective cohort study. Environ Int. 2022 May;163:107229. doi: 10.1016/j.envint.2022.107229
- Scelo G, Maule MM, Richiardi L. Cancers emerging early in adulthood: Analysis of trends and patterns in European cancer registries. Eur J Cancer. 2021 Jan;143:33-39. doi: 10.1016/j.ejca.2020.10.026
- Richiardi L, Bellocco R, Zugna D. Mediation analysis in epidemiology: methods, interpretation and bias. Int J Epidemiol. 2013 Oct;42(5):1511-9. doi: 10.1093/ije/dyt127
- Zugna D, Galassi C, Annesi-Maesano I, Baïz N, Barros H, Basterrechea M, Correia S, Duijts L, Esplugues A, Fantini MP, Forastiere F, Gascon M, Gori D, Inskip H, Larsen PS, Mommers M, Nybo Andersen AM, Penders J, Petersen MS, Pike K, Porta D, Sonnenschein-van der Voort A, Steuerwald U, Sunyer J, Torrent M, Vrijheid M, Richiardi L, Rusconi F. Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts. Int J Epidemiol. 2015 Feb;44(1):199-208. doi: 10.1093/ije/dyu260
- 2017 - OMEGA-NET: Network on the Coordination and Harmonization of European Occupational Cohorts website - EU Cost Action
- 2017 - LIFECYCLE: Early-life stressors and LifeCycle health website - Horizon 2020
- 2017 - Ambiente e i primi 1000 giorni website - Ministero della Salute e Centro nazionale per la prevenzione e il controllo delle malattie (CCM)
- 2018 - STOP: Science and Technology in childhood Obesity Policy website - Horizon 2020
- 2019 - E-OMEGA: Environmental and Occupational Mega European Cohort - Compagnia di San Paolo - Bando Ex-Post 2018
- 2019 - Headspace: Translational Studies of Head and Neck Cancer in South America and Europe website - Horizon 2020
- 2020 - ATHLETE: Advancing Tools for Human Early Lifecourse Exposome Research and Translation website Horizon 2020
- 2021 – TPCP: Improving prostate cancer prognostication through an integrated approach website - AIRC
- 2022 – GOLIAT: 5G expOsure, causaL effects, and rIsk perception through citizen engagement website – Horizon Europe
- 2022 - PNC Ambiente e Salute: Valutazione dell'esposoma nei primi 1000 giorni in coorti di nati in aree ad elevata antropizzazione e attuazione di interventi per la riduzione del rischio - Ministero della Salute
- 2023 – DISCERN: Discovering the Causes of Three Poorly Understood Cancers in Europe website - Horizon Europe
- NINFEA Project: NINFEA (Birth and Infancy: the Effects of the Environment) is a web-based cohort, which enrolled more than 7 thousand women in Italy between 2005 and 2016 during pregnancy and follows their children up over time with periodic questionnaires (at ages 6 and 18 months and 4, 7, 10, 13 and 16 years). The NINFEA project, which is conducted entirely via the Internet, uses innovative forms of "multichannel" communication aimed at both the participants and a wider audience. The main means of communication is the website www.progettoninfea.it, which includes the description of the various components of the project, a press review, a list of scientific publications, news updates, a data section and links to the project's social channels.
- “Ambiente e i primi 1000 giorni” (website) is a research project funded by the Ministry of Health and the National Center for Disease Prevention and Control (NCCM) in which the research group took part developing, as part of a multidisciplinary team from various national institutions, a dissemination website with the overall objective of providing evidence on the burden of exposure in the first 1000 days of life, in particular environmental exposures, on potential useful interventions, and on the role of epigenetic alterations in different contexts in Italy.
- CPO Piedmont www.cpo.it : the group participates in many activities carried out by the Reference Center for Epidemiology and Cancer Prevention in Piedmont; the communication and dissemination activities of the Center are based on the website and on social channels Twitter and YouTube.
- A number of external communication sites aimed at presenting particular research initiatives have been activated; for example the TPCP (Turin Prostate Cancer Prognostication), study an observational cohort study launched in 2021 (TPCP website), and the EPSAM project (EPSAM website) aimed at investigating risk factors for testicular cancer.