Department of Medical Sciences

Research products

Selected research products

Mazzeo A, Beltramo E, Iavello A, Carpanetto A, Porta M. (2015) Molecular mechanisms of extracellular vesicle-induced vessel destabilization in diabetic retinopathy. Acta diabetologica [DOI  PMID]

Beltramo E, Lopatina T, Berrone E, Mazzeo A, Iavello A, Camussi G, Porta M. (2014) Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro. Acta diabetologica 51(6) 1055-64 [DOI  PMID]

Beltramo E, Porta M. (2013) Pericyte loss in diabetic retinopathy: mechanisms and consequences. Current medicinal chemistry 20(26) 3218-25 [PMID]

Tarallo S, Beltramo E, Berrone E, Porta M. (2012) Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment. Acta diabetologica 49 Suppl 1 S141-51 [DOI  PMID]

Beltramo E, Nizheradze K, Berrone E, Tarallo S, Porta M. (2009) Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes. Diabetes/metabolism research and reviews 25(7) 647-56 [DOI  PMID]

Beltramo E, Berrone E, Tarallo S, Porta M. (2009) Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine. Diabetes/metabolism research and reviews 25(6) 566-76 [DOI  PMID]

Tarallo S, Beltramo E, Berrone E, Dentelli P, Porta M. (2010) Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cells. Acta diabetologica 47(2) 105-11 [DOI  PMID]

Berrone E, Beltramo E, Buttiglieri S, Tarallo S, Rosso A, Hammes HP, Porta M. (2009) Establishment and characterization of a human retinal pericyte line: a novel tool for the study of diabetic retinopathy. International journal of molecular medicine 23(3) 373-8 [PMID]

Beltramo E, Berrone E, Tarallo S, Porta M. (2008) Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications. Acta diabetologica 45(3) 131-41 [DOI  PMID]

Beltramo E, Berrone E, Giunti S, Gruden G, Perin PC, Porta M. (2006) Effects of mechanical stress and high glucose on pericyte proliferation, apoptosis and contractile phenotype. Experimental eye research 83(4) 989-94 [DOI  PMID]

Berrone E, Beltramo E, Solimine C, Ape AU, Porta M. (2006) Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. The Journal of biological chemistry 281(14) 9307-13 [DOI  PMID]

Matera L, Beltramo E, Martinuzzi E, Buttiglieri S. (2004) Effect of prolactin on carcinoembryonic antigen-specific cytotoxic T lymphocyte response induced by dendritic cells. Clinical and experimental immunology 137(2) 320-8 [DOI  PMID]

Beltramo E, Berrone E, Buttiglieri S, Porta M. (2004) Thiamine and benfotiamine prevent increased apoptosis in endothelial cells and pericytes cultured in high glucose. Diabetes/metabolism research and reviews 20(4) 330-6 [DOI  PMID]

Pomero F, Allione A, Beltramo E, Buttiglieri S, D'Alu F, Ponte E, Lacaria A, Porta M. (2003) Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes. Diabetologia 46(3) 416-9 [DOI  PMID]

Beltramo E, Buttiglieri S, Pomero F, Allione A, D'Alu F, Ponte E, Porta M. (2003) A study of capillary pericyte viability on extracellular matrix produced by endothelial cells in high glucose. Diabetologia 46(3) 409-15 [DOI  PMID]

Limone P, Berardi C, Pomero F, Del Rizzo P, Allione A, Beltramo E, D'alu F, Ponte E, Pellissetto C, Lacaria A, Barberis AM, Porta M. (2002) Failure of angiotensin II and insulin to stimulate transforming growth factor-beta1. Release from cultured bovine retinal pericytes. Diabetes & metabolism 28(6 Pt 1) 499-503 [PMID]

Beltramo E, Pomero F, Allione A, D'Alu F, Ponte E, Porta M. (2002) Pericyte adhesion is impaired on extracellular matrix produced by endothelial cells in high hexose concentrations. Diabetologia 45(3) 416-9 [DOI  PMID]

Brignardello E, Beltramo E, Molinatti PA, Aragno M, Gatto V, Tamagno E, Danni O, Porta M, Boccuzzi G. (1998) Dehydroepiandrosterone protects bovine retinal capillary pericytes against glucose toxicity. The Journal of endocrinology 158(1) 21-6 [PMID]

La Selva M, Beltramo E, Pagnozzi F, Bena E, Molinatti PA, Molinatti GM, Porta M. (1996) Thiamine corrects delayed replication and decreases production of lactate and advanced glycation end-products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose conditions. Diabetologia 39(11) 1263-8 [PMID]

La Selva M, Beltramo E, Passera P, Porta M, Molinatti GM. (1993) The role of endothelium in the pathogenesis of diabetic microangiopathy. Acta diabetologica 30(4) 190-200 [PMID]

Dosso AA, Brooks RA, Beltramo E, Molinatti PA, Kanse SM, Kohner EM, Porta M. (1993) A study of the effects of human blood derivatives and individual growth factors on [3H]thymidine uptake in bovine retinal pericytes and endothelial cells. Acta diabetologica 30(4) 207-13 [PMID]

La Selva M, Chiara P, Muccini E, Beltramo E, Molinatti PA, Porta M, Molinatti GM. (1992) Delayed replication of human umbilical vein endothelial cells in high glucose is corrected by L-tyrosine. Diabetes research (Edinburgh, Scotland) 19(2) 87-90 [PMID]

Research topics

Ricerca

• Dal 2000 a tutt’oggi: coordinatrice della ricerca di base dell’unità di Retinopatia diabetica diretta dal prof. Massimo Porta presso il Dipartimento di Scienze mediche dell'Università di Torino.

Studio dei meccanismi biochimici e molecolari alla base dell’etiopatogenesi delle complicanze microvascolari del diabete, in particolare della retinopatia diabetica. Sviluppo di modelli di coltura singola e di co-coltura di cellule microvascolari retiniche (endotelio e periciti), per studiare i meccanismi intracellulari del danno causato dall’eccesso di glucosio in circolo. Studio del possibile ruolo di molecole e farmaci nella correzione di tale danno. Creazione di linee cellulari immortalizzate per standardizzare i modelli di coltura. Studio delle interazioni tra matrice extracellulare, periciti ed endotelio e dell’influenza su di esse dell’ambiente microvascolare simil-diabetico.

• Stesura e rendicontazione di progetti di ricerca nazionali ed internazionali (Compagnia di San Paolo, Società Italiana di Diabetologia, Regione Piemonte, MIUR, EFSD - European Foundation for the Study of Diabetes, JDRF – Juvenile Diabetes Research Foundation, VII European Framework Programme – Health 2011, Horizon 2020).
• Reviewer per riviste internazionali, quali Experimental Eye Research, Molecular Vision, Journal of Molecular and Cellular Cardiology, Clinical Ophthalmology, Pharmacological Research, Diabetes Metabolism Research and Reviews, Molecular and Cellular Biochemistry, Expert Opinion On Therapeutic Targets, Acta Diabetologica.

Supporto alla didattica

• Tutor tirocinio pratico e preparazione tesi studenti corsi di laurea in Tecniche di Laboratorio biomedico e Biotecnologie.
• Tutor attività di laboratorio e preparazione tesi studenti corso di laurea in Medicina e Chirurgia, specializzandi in Medicina interna, Endocrinologia e Patologia clinica, dottorandi di ricerca in Patologia clinica e Fisiopatologia medica.

Gruppi di ricerca

Retinopatia diabetica

Research groups

• of Diabetic Retinopathy

Research projects

• Eurocondor
• Eurocondor

• Eurocondor

Activities in agenda

See my calendar

Academic bodies

• DSM Department Board 2021_2024
• Junta

• Commissione Ricerca
• Commissione Scarichi Inventariali
• Commissione Terza Missione 2023
• Consiglio
• Giunta