In vivo functional studies with tracers infusion
The facility
In vivo tracer studies (with stable isotope), allow exploring metabolic flexibility in response to a glucose (oral glucose tolerance test, OGTT) or a lipid (oral lipid tolerance test, OLTT) load. Metabolic fluxes analysis, such as endogenous glucose production, glucose clearance and adipose tissue lipolysis, represent the gold standard for the measurement of insulin resistance components (hepatic, muscle and adipose tissue insulin resistance). Insulin resistance is the most important mechanism involved in the progression of liver damage in subjects with non-alcoholic fatty liver disease (NAFLD) and is implicated in other metabolic conditions such as type 2 diabetes.
Prof. Elisabetta Bugianesi, MD, Ph.D.
Full Professor
Dept. of Medical Sciences, Via San Massimo 24 -10123 Torino
Phone: +39 0116333541
Fax +39 0116333976
Chiara Rosso, MsC
Research Technician
Dept. of Medical Sciences, Via San Massimo 24 -10123 Torino
Tel. +39 0116333532
In vivo studies with tracer infusion are performed at the University Hospital Città della Salute e della Scienza (Corso Bramante 88) under day hospital regimen with the supervision of an expert medical and nursing staff. For more information about these studies please send an e-mail to chiara.rosso@unito.it.
- Armandi A, Rosso C, Nicolosi A, et al. Crosstalk between irisin levels, liver fibrogenesis and liver damage in non-obese, non-diabetic individuals with non-alcoholic fatty liver disease. J Clin Med. 2022;11:635. doi: 10.3390/jcm11030635.
- Armandi A, Rosso C, Caviglia GP, Bugianesi E. Insulin resistance across the spectrum of non alcoholic fatty liver disease. Metabolites 2021;11:155. doi: 10.3390/metabo11030155.
- Rosso C, Kazankov K, Younes R, et al. Crosstalk between adipose tissue insulin resistance and liver macrophages in non-alcoholic fatty liver disease. J Hepat 2019;71:1012-21.
- Gaggini M, Carli F, Rosso C, et al. Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance. Hepatology. 2018;67:145-58.
- Rosso C, Mezzabotta L, Gaggini M, et al. Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease. Hepatology. 2016;63:107-16.
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