Department of Medical Sciences

Selected research products

10 selected papers.

 

Deaglio, S., K.M. Dwyer, W. Gao, D. Friedman, A. Usheva, A. Erat, J.F. Chen, K. Enjyoji, J. Linden, M. Oukka, V.K. Kuchroo, T.B. Strom, and S.C. Robson. 2007. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 204:1257-1265.

 

Malavasi, F., S. Deaglio, A. Funaro, E. Ferrero, A.L. Horenstein, E. Ortolan, T. Vaisitti, and S. Aydin. 2008. Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiol Rev 88:841-886.

 

Serra, S., A.L. Horenstein, T. Vaisitti, D. Brusa, D. Rossi, L. Laurenti, G. D'Arena, M. Coscia, C. Tripodo, G. Inghirami, S.C. Robson, G. Gaidano, F. Malavasi, and S. Deaglio. 2011. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. Blood 118:6141-6152.

 

Saborit-Villarroya, I., T. Vaisitti, D. Rossi, G. D'Arena, G. Gaidano, F. Malavasi, and S. Deaglio. 2011. E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemia. Leukemia 25:479-488.

 

Rossi, D., V. Trifonov, M. Fangazio, A. Bruscaggin, S. Rasi, V. Spina, S. Monti, T. Vaisitti, F. Arruga, R. Fama, C. Ciardullo, M. Greco, S. Cresta, D. Piranda, A. Holmes, G. Fabbri, M. Messina, A. Rinaldi, J. Wang, C. Agostinelli, P.P. Piccaluga, M. Lucioni, F. Tabbo, R. Serra, S. Franceschetti, C. Deambrogi, G. Daniele, V. Gattei, R. Marasca, F. Facchetti, L. Arcaini, G. Inghirami, F. Bertoni, S.A. Pileri, S. Deaglio, R. Foa, R. Dalla-Favera, L. Pasqualucci, R. Rabadan, and G. Gaidano. 2012. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med 209:1537-1551.

 

Arruga, F., B. Gizdic, S. Serra, T. Vaisitti, C. Ciardullo, M. Coscia, L. Laurenti, G. D'Arena, O. Jaksic, G. Inghirami, D. Rossi, G. Gaidano, and S. Deaglio. 2014. Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia. Leukemia 28:1060-1070.

 

Audrito, V., S. Serra, D. Brusa, F. Mazzola, F. Arruga, T. Vaisitti, M. Coscia, R. Maffei, D. Rossi, T. Wang, G. Inghirami, M. Rizzi, G. Gaidano, J.G. Garcia, C. Wolberger, N. Raffaelli, and S. Deaglio. 2015. Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia. Blood 125:111-123.

 

Vaisitti, T., V. Audrito, S. Serra, R. Buonincontri, G. Sociali, E. Mannino, A. Pagnani, A. Zucchetto, E. Tissino, C. Vitale, M. Coscia, C. Usai, C. Pepper, V. Gattei, S. Bruzzone, and S. Deaglio. 2015. The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting. Leukemia 29:356-368.

 

Bologna, C., R. Buonincontri, S. Serra, T. Vaisitti, V. Audrito, D. Brusa, A. Pagnani, M. Coscia, G. D'Arena, E. Mereu, R. Piva, R.R. Furman, D. Rossi, G. Gaidano, C. Terhorst, and S. Deaglio. 2016. SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response. The Journal of clinical investigation 126:181-194.

 

Arruga, F., B. Gizdic, C. Bologna, S. Cignetto, R. Buonincontri, S. Serra, T. Vaisitti, K. Gizzi, N. Vitale, G. Garaffo, E. Mereu, F. Diop, F. Neri, D. Incarnato, M. Coscia, J. Allan, R. Piva, S. Oliviero, R.R. Furman, D. Rossi, G. Gaidano, and S. Deaglio. 2016, in press. Mutations in NOTCH1 PEST-domain orchestrate CCL19-driven homing of Chronic Lymphocytic Leukemia cells by modulating the tumor suppressor gene DUSP22. Leukemia

Courses

• ADE Genetica e medicina dei trapianti (SME1020)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Basi biologiche, molecolari e di genetica umana (canale A) (SME0881)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• GENETICA MEDICA (MED3166B)
  Corso di Laurea in Infermieristica Pediatrica
• Genetica Medica (D.M.270/04) (MED 2889B)
  Corso di Laurea in Tecniche di Laboratorio Biomedico - Torino
• Genetica Medica (canale A) (SME0737A)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Genetica umana (canale A) (SME0881C)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• I. TECNICHE DI DIAGNOSI DELLE MALATTIE GENETICHE (D.M. 270/04) (MED 2889)
  Corso di Laurea in Tecniche di Laboratorio Biomedico - Torino
• Medicina Interna I (canale A) (SME0737)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• PROBLEMI DI SALUTE IN AREA PERINATALE (MED3166)
  Corso di Laurea in Infermieristica Pediatrica
• Ruolo di NOTCH1 nel favorire lo sviluppo e la progressione della leucemia linfatica cronica. Responsabile prof Silvia Deaglio
  Programma MD-PhD della Scuola di Medicina
• TIROCINIO di GENETICA DEI TRAPIANTI DI ORGANO, TESSUTI E CELLULE (SME0705)
  Corso di Laurea Magistrale in Biotecnologie Mediche - Classe LM-9
• TIROCINIO di IMMUNOGENETICA DEI TUMORI (SME0871)
  Corso di Laurea Magistrale in Biotecnologie Mediche - Classe LM-9

Research topics

After obtaining an MD degree and training as a medical oncologist, I started a PhD program in Genetics at the University of Turin. My research interests were focused on enzymes that can synthesize and metabolize nucleotides, such as ATP and NAD, in the extracellular environment. During the PhD, I trained at the Beth Israel Deaconess Medical Center of Harvard University with Drs. Simon Robson and Terry Strom, where we identified an ATP-degrading pathway as an integral component of the suppressive machinery of regulatory T cells. After going back to Italy at the end of 2005, I obtained my first two grants as an independent investigator and studied nucleotide-nucleoside balance in the tumor microenvironment. In 2010 I started my own research group in the Laboratories of the Human Genetics Foundation in Turin, Italy. This group now comprises 12 researchers. In the past few years we have focused on NAD metabolism as a critical step in the regulation of leukemic cell homing and in the skewing of bystander cells towards a pro-survival phenotype. Furthermore, we participated in a joint effort to identify recurrently mutated genes in patients with chronic lymphocytic leukemia and splenic marginal zone lymphoma. Current studies are dedicated to the understanding of the role of these genes and their mutations in the biology of the disease. To do this, there is an urgent need of xenograft models that will allow expansion of genetically-typed primary cells. In order to implement these models in the lab, I spent two years as a visiting professor at Weill Cornell Medical College. Upon returning to Turin in September 2016, I obtained a clinical position in the Transplant Immunology Unit of the local University Hospital to work on immune-mediated transplant rejection.  

 

Gruppi di ricerca

Immunogenetica dei tumori

Genetica e Immunologia dei Trapianti

Research projects

• INTEGRATA

• A ménage à trois involving the B cell receptor, NOTCH1 and NAMPT: therapeutic implications for CLL and RS patients”
• INTEGRATA
• Circulating NAD biosynthetic enzymes (NBEs) as novel prognostic markers in chronic lymphocytic leukemina and Richter's syndrome
• Understanding and targeting the extracellular NADome in inflammation

Academic bodies

• DSM Department Board 2021_2024

• Commissione Ricerca
• Consiglio
• Giunta

• Comitato didattico scientifico - Programma MD-PhD

Office hours

Venerdì dalle 16 alle 18, su appuntamento (silvia.deaglio@unito.it)